NCE DP6 In-situ Fiber Optic spectrometer
The NCE DP6 in-situ fiber spectrometer combines a deuterium light source with a photodiode array detector to capture key insights into drug dissolution in real time with in-situ fiber technology.
- The sampling interval can be flexibly modified
- Eliminates Complex Pretreatment
- Supports up to 6 channels of optical fiber
Key features
The dissolution dynamics in the medium can be accurately captured within 5 seconds for fast-release samples, which can reflect the drug release behavior in real time.
Measures concentration directly in the analytical medium, enabling fully automated, 24-hour unattended operation.
Significantly enhancing analysis efficiency and ensuring data consistency and comparability.
The integrated software automatically generates detailed reports upon experiment completion, intuitively visualizing how formulations impact the dissolution, solubility, and permeability of the Active Pharmaceutical Ingredient (API).
Applications
Drugs have complex dissolution and permeation behaviors in the body, so the impact of the in vivo environment on the drug needs to be considered during the early drug development or prescription modification process. For this purpose, it is necessary to construct an in vitro environment that can simulate the in vivo environment for experimental research.
- Intrinsic Dissolution Rate Test
- PH Shift Model
- Permeation Model
Technical specifications
- Wavelength range
- 200-600nm
- Wavelength accuracy
- ± 1nm
- Deuterium lamp life
- >1000 hours
- Absorbance range
- Up to 2AU
- Baseline flatness
- ≤0.002AU
- Minimum sampling interval
- 2 seconds
- —
- Noise ≤ 0.002 AU(under 600nm conditions)
- Fiber channel
- 6
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